作者
Chiara Arrigoni, Silvia Lopa, Christian Candrian, Matteo Moretti
发表日期
2020/6/1
来源
Current opinion in biotechnology
卷号
63
页码范围
79-88
出版商
Elsevier Current Trends
简介
Highlights
- The study of multifactorial diseases needs in vitro models involving complex interactions.
- Model complexity can be of biological or technological nature.
- Final applications (HTS, Personalized, Basic science) define the model complexity characteristics.
- Musculoskeletal-tissues-on-chip for the study of specific musculoskeletal diseases are critically reviewed.
Multifactorial diseases affecting musculoskeletal tissues are characterized by the interactions between multiple tissues, such as muscle and nerves in neuromuscular diseases, or multiple cellular components in a tissue, as in the case of bone tumors, interacting with bone cells. For these diseases also the influence of different biophysical and biochemical stimuli, such as mechanical overload and inflammatory molecules in osteoarthritis, play a key role. To investigate these complex phenomena, organ-on-a-chip systems have been developed, taking into …
学术搜索中的文章
C Arrigoni, S Lopa, C Candrian, M Moretti - Current opinion in biotechnology, 2020