作者
Hussein Osman Ammar, SA El-Nahhas, MM Ghorab, AH Salama
发表日期
2012/2
期刊
Journal of Inclusion Phenomena and Macrocyclic Chemistry
卷号
72
页码范围
127-136
出版商
Springer Netherlands
简介
One of the most attractive areas of research in drug delivery is the design of nanomedicines consisting of nanosystems that are able to deliver drugs to the right place, at appropriate time. Natural polysaccharides, due to their outstanding merits, have received more and more attention in the field of drug delivery systems. In particular, polysaccharides seem to be the most promising materials in the preparation of nanometric carriers. The main goal of the present study was to investigate the potential of a recent generation of hybrid polysaccharide nanocarriers, composed of chitosan (CS) and an anionic cyclodextrin, carboxymethyl-β-cyclodextrin (CM-β-CD), for the encapsulation of a model drug, sulindac. CS and CM-β-CD were processed to nanoparticles (NPs) via the ionotropic gelation technique. The stoichiometric ratio between these two polymers was found to influence particle size and zeta potential …
学术搜索中的文章
HO Ammar, SA El-Nahhas, MM Ghorab, AH Salama - Journal of Inclusion Phenomena and Macrocyclic …, 2012