作者
International Genomics of Alzheimer's Disease Consortium (IGAP), Lesley Jones, Jean‐Charles Lambert, Li‐San Wang, Seung‐Hoan Choi, Denise Harold, Alexey Vedernikov, Valentina Escott‐Price, Timothy Stone, Alexander Richards, Céline Bellenguez, Carla A Ibrahim‐Verbaas, Adam C Naj, Rebecca Sims, Amy Gerrish, Gyungah Jun, Anita L DeStefano, Joshua C Bis, Gary W Beecham, Benjamin Grenier‐Boley, Giancarlo Russo, Tricia A Thornton‐Wells, Nicola Jones, Albert V Smith, Vincent Chouraki, Charlene Thomas, M Arfan Ikram, Diana Zelenika, Badri N Vardarajan, Yoichiro Kamatani, Chiao‐Feng Lin, Helena Schmidt, Brian W Kunkle, Melanie L Dunstan, Agustin Ruiz, Marie‐Thérèse Bihoreau, Christiane Reitz, Florence Pasquier, Paul Hollingworth, Olivier Hanon, Annette L Fitzpatrick, Joseph D Buxbaum, Dominique Campion, Paul K Crane, Tim Becker, Vilmundur Gudnason, Carlos Cruchaga, David Craig, Najaf Amin, Claudine Berr, Oscar L Lopez, Philip L De Jager, Vincent Deramecourt, Janet A Johnston, Denis Evans, Simon Lovestone, Luc Letteneur, Johanes Kornhuber, Lluís Tárraga, David C Rubinsztein, Gudny Eiriksdottir, Kristel Sleegers, Alison M Goate, Nathalie Fiévet, Matthew J Huentelman, Michael Gill, Valur Emilsson, Kristelle Brown, M Ilyas Kamboh, Lina Keller, Pascale Barberger‐Gateau, Bernadette McGuinness, Eric B Larson, Amanda J Myers, Carole Dufouil, Stephen Todd, David Wallon, Seth Love, Pat Kehoe, Ekaterina Rogaeva, John Gallacher, Peter St George‐Hyslop, Jordi Clarimon, Alberti Lleò, Anthony Bayer, Debby W Tsuang, Lei Yu, Magda Tsolaki, Paola Bossù, Gianfranco Spalletta, Petra Proitsi, John Collinge, Sandro Sorbi, Florentino Sanchez Garcia, Nick Fox, John Hardy, Maria Candida Deniz Naranjo, Cristina Razquin, Paola Bosco, Robert Clarke, Carol Brayne, Daniela Galimberti, Michelangelo Mancuso, MRC CFAS, Susanne Moebus, Patrizia Mecocci, Maria del Zompo, Wolfgang Maier, Harald Hampel, Alberto Pilotto, Maria Bullido, Francesco Panza, Paolo Caffarra, Benedetta Nacmias, John R Gilbert, Manuel Mayhaus, Frank Jessen, Martin Dichgans, Lars Lannfelt, Hakon Hakonarson, Sabrina Pichler, Minerva M Carrasquillo, Martin Ingelsson, Duane Beekly, Victoria Alavarez, Fanggeng Zou, Otto Valladares, Steven G Younkin, Eliecer Coto, Kara L Hamilton‐Nelson, Ignacio Mateo, Michael J Owen, Kelley M Faber, Palmi V Jonsson, Onofre Combarros, Michael C O'Donovan, Laura B Cantwell, Hilkka Soininen, Deborah Blacker, Simon Mead, Thomas H Mosley Jr, David A Bennett, Tamara B Harris, Laura Fratiglioni, Clive Holmes, Renee FAG de Bruijn, Peter Passmore, Thomas J Montine, Karolien Bettens, Jerome I Rotter
发表日期
2015/6
期刊
Alzheimer's & Dementia
卷号
11
期号
6
页码范围
658-671
简介
Background
Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis.
Methods
The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain.
Results
ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (P = 3.27 × 10−12 after multiple testing correction for pathways), regulation of endocytosis (P = 1.31 × 10−11), cholesterol transport (P = 2.96 × 10−9), and proteasome‐ubiquitin activity (P = 1.34 × 10−6). Correlated gene expression analysis identified four significant network modules, all related to the …
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… Genomics of Alzheimer's Disease Consortium (IGAP)… - Alzheimer's & Dementia, 2015