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The aim of this study was to determine the effect of selected relaxing music on anxiety and depression in patients during hemodialysis. This crossover clinical trial involved 102 patients undergoing hemodialysis at a leading hospital in an urban setting. Patients were randomly assigned to groups A (treatment) and B (control) and their levels of anxiety and depression at the beginning and the end of the hemodialysis were measured using Spielberger State-Trait Anxiety Inventory and Beck Depression Inventory tests, respectively. Both groups consecutively, and with a two-week washout, listened to experimenter selected instrumental music on their earphones individually for three hours. Data were analyzed using SPSS software, version 18. No significant differences in BDI-II (P = 0.253), t-anxiety (P = 0.546), and s-anxiety (P = 0.253), T-Anxiety (P = 0.546), and S-Anxiety (P = 0.776) was observed between the two …