作者
Calum Johnston, Nathalie Campo, Matthieu J Bergé, Patrice Polard, Jean-Pierre Claverys
发表日期
2014/3/1
来源
Trends in microbiology
卷号
22
期号
3
页码范围
113-119
出版商
Elsevier
简介
Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Natural genetic transformation, which was discovered in this species, involves internalization of exogenous single-stranded DNA and its incorporation into the chromosome. It allows acquisition of pathogenicity islands and antibiotic resistance and promotes vaccine escape via capsule switching. This opinion article discusses how recent advances regarding several facets of pneumococcal transformation support the view that the process has evolved to maximize plasticity potential in this species, making the pneumococcus le transformiste of the bacterial kingdom and providing an advantage in the constant struggle between this pathogen and its host.
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C Johnston, N Campo, MJ Bergé, P Polard… - Trends in microbiology, 2014