作者
Andrew JO Whitehouse, Eugen Mattes, Murray T Maybery, Michael G Sawyer, Peter Jacoby, Jeffrey A Keelan, Martha Hickey
发表日期
2012/7
期刊
Journal of Child Psychology and Psychiatry
卷号
53
期号
7
页码范围
726-734
出版商
Blackwell Publishing Ltd
简介
Background:  Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. However, no study has examined a large sample of children at multiple time‐points.
Methods:  Umbilical cord blood samples were obtained at 861 births and analysed for bioavailable testosterone (BioT) concentrations. When participating offspring were 1, 2 and 3 years of age, parents of 767 children (males = 395; females = 372) completed the Infant Monitoring Questionnaire (IMQ), which measures Communication, Gross Motor, Fine Motor, Adaptive and Personal–Social development. Cut‐off scores are available for each scale at each age to identify children with ‘clinically significant’ developmental delays. Chi‐square analyses and generalized estimating equations examined longitudinal associations between sex‐specific quartiles of BioT concentrations and the rate of …
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