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Dietary compounds are reported to have the innate ability to interfere several diseases. D-Pinitol is one of the compounds from dietary origin, well documented for its excellent biological activities. We have reported the therapeutic efficiency of the D-Pinitol with reference to lipid peroxidation, antioxidants, drug metabolizing enzymes and expressions of proteins such as p53, Bcl-2, and caspase-3 during DMBA-induced mammary carcinogenesis. D-Pinitol at the dose of 200 mg/kg body weight was administered orally to treat the breast cancer-bearing animals for consecutive 45 days. Interestingly, D-Pinitol significantly decreased the lipid peroxidation and increased the antioxidants and modulated the biotransformation enzymes to near normal level when compared to control. The western blotting and RT-PCR analysis also inevitably confirms that D-Pinitol treatment down regulated the expression of Bcl-2 and up …