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Patients in the intensive care unit (ICU) carry a poor prognosis not only owing to their critical illness but also due to predisposition to nosocomial infections. In addition to their association with increased morbidity and mortality, patients have to bear the onslaught of nosocomial infections with drug-resistant microorganisms, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci (VRE) and extended spectrum β-lactamase (ESBL) producing Gram-negative bacteria, which can pose considerable therapeutic problems.[1] Nosocomial infections can affect any part of the body but respiratory tract infections are the most frequent