作者
Pierre-Grégoire Guinot, Alexandra Spitz, Vivien Berthoud, Omar Ellouze, Anis Missaoui, Tiberiu Constandache, Sandrine Grosjean, Mohamed Radhouani, Jean-Baptiste Anciaux, Jean-Philippe Parthiot, Jean-Pierre Merle, Nicolas Nowobilski, Maxime Nguyen, Belaid Bouhemad
发表日期
2019/12
期刊
BMC anesthesiology
卷号
19
页码范围
1-10
出版商
BioMed Central
简介
Background
No study has been conducted to demonstrate the feasibility of an opioid-free anesthesia (OFA) protocol in cardiac surgery to improve patient care. The aim of the present study was to evaluate the effect of OFA on post-operative morphine consumption and the post-operative course.
Methods
After retrospectively registering to clinicaltrial.gov (NCT03816592), we performed a retrospective matched cohort study (1:1) on cardiac surgery patients with cardiopulmonary bypass between 2018 and 2019. Patients were divided into two groups: OFA (lidocaine, dexamethasone and ketamine) or opioid anaesthesia (OA) (sufentanil). The main outcome was the total postoperative morphine consumption in the 48 h after surgery. Secondary outcomes were rescue analgesic use, a major adverse event composite endpoint, and ICU and hospital length of …
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PG Guinot, A Spitz, V Berthoud, O Ellouze, A Missaoui… - BMC anesthesiology, 2019