作者
Sara Rollinson, Janis Bennion, Greg Toulson, Nicola Halliwell, Suzanne Usher, Julie Snowden, Anna Richardson, David Neary, David Mann, Stuart M Pickering-Brown
发表日期
2012/2/1
期刊
Neurobiology of aging
卷号
33
期号
2
页码范围
425. e1-425. e2
出版商
Elsevier
简介
Frontotemporal lobar degeneration (FTLD) can occur jointly with amyotrophic lateral sclerosis (ALS), and these 2 conditions share a genetic risk factor on chromosome 9. It has been reported that mutations in optineurin (OPTN) can cause ALS. Therefore, we sequenced OPTN in 371 FTLD cases but no mutations were detected, suggesting changes in OPTN do not cause FTLD.
学术搜索中的文章
S Rollinson, J Bennion, G Toulson, N Halliwell… - Neurobiology of aging, 2012