作者
Nathaniel Rothman, Christine F Skibola, Sophia S Wang, Gareth Morgan, Qing Lan, Martyn T Smith, John J Spinelli, Eleanor Willett, Silvia De Sanjose, Pierluigi Cocco, Sonja I Berndt, Paul Brennan, Angela Brooks-Wilson, Sholom Wacholder, Nikolaus Becker, Patricia Hartge, Tongzhang Zheng, Eve Roman, Elizabeth A Holly, Paolo Boffetta, Bruce Armstrong, Wendy Cozen, Martha Linet, F Xavier Bosch, Maria Grazia Ennas, Theodore R Holford, Richard P Gallagher, Sara Rollinson, Paige M Bracci, James R Cerhan, Denise Whitby, Patrick S Moore, Brian Leaderer, Agnes Lai, Charlotte Spink, Scott Davis, Ramon Bosch, Aldo Scarpa, Yawei Zhang, Richard K Severson, Meredith Yeager, Stephen Chanock, Alexandra Nieters
发表日期
2006/1/1
期刊
The lancet oncology
卷号
7
期号
1
页码范围
27-38
出版商
Elsevier
简介
Background
Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph).
Methods
We selected 12 single-nucleotide polymorphisms for analysis, on the basis of previous functional or association data, in nine genes that have important roles in lymphoid development, Th1/Th2 balance, and proinflammatory or anti-inflammatory pathways (IL1A, IL1RN, IL1B, IL2, IL6, IL10, TNF, LTA, and CARD15). Genotype data for one or more single-nucleotide polymorphisms were available for 3586 cases of non-Hodgkin lymphoma and for 4018 controls, and were assessed in a pooled analysis by use of a random-effects logistic regression model.
Findings
The …
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