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Imaging Somatostatin Subtype Receptor 2 (SST₂) expressing macrophages by [DOTA,Tyr³]-octreotate (DOTATATE) has proven successful for plaque detection. DOTA-JR11 is a SST₂ targeting ligand with a five times higher tumor uptake than DOTATATE, and holds promise to improve plaque imaging. The aim of this study was to evaluate the potential of DOTA-JR11 for plaque detection.

Atherosclerotic ApoE^−/− mice (n = 22) fed an atherogenic diet were imaged by SPECT/CT two hours post injection of [¹¹¹In]In-DOTA-JR11 (~ 200 pmol, ~ 50 MBq). In vivo plaque uptake of [¹¹¹In]In-DOTA-JR11 was visible in all mice, with a target-to-background-ratio (TBR) of 2.23 ± 0.35. Post-mortem scans after thymectomy and ex vivo scans of the arteries after excision of the arteries confirmed plaque uptake of the radioligand with TBRs of 2.46 ± 0.52 and 3.43 ± 1.45 respectively. Oil red O lipid …