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To determine the feasibility of MRI texture analysis as a method of quantifying subchondral bone architecture in knee osteoarthritis (OA).

Asymptomatic subjects aged 20–30 (group 1, n = 10), symptomatic patients aged 40–50 (group 2, n = 10) and patients scheduled for knee replacement aged 55–85 (group 3, n = 10) underwent high spatial resolution T1-weighted coronal 3T knee MRI.

Regions of interest were created in the medial (MT) and lateral (LT) tibial subchondral bone from which 20 texture parameters were calculated. T2 mapping of the tibial cartilage was performed in groups 1 and 2. Mean parameter values were compared between groups using ANOVA. Linear discriminant analysis (LDA) was used to evaluate the ability of texture analysis to classify subjects correctly.