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We compared the effect of two selective dopamine D₁ receptor agonists, SKF 38393 ((±)-1-phenyl-2,3,4,5-tetrahydro-(1H)- 3-benzazepine-7,8-diol · HCl) and A68930 ((1R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman · HCl), and that of imipramine in the behavioural despair model of depression. The dopamine D₁ receptor agonists and impramine showed an anti-immobility effect. Moreover we found that the ‘antidepressant’ effect of imipramine in the behavioural despair test was antagonized by SCH 23390, a selective dopamine D₁ receptor blocker. The results further support the hypothesis that dopamine D₁ receptor stimulation plays an important role in the mechanism of action of amtidepressants and suggest that dopamine D₁ receptor agonists might be considered as potential antidepressant drugs.