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Percutaneous image-guided biopsy plays an integral role in the management of breast lesions identified on imaging studies, with reported rates of up to 1%-8% of women enrolled in a screening mammography program undergoing percutaneous breast biopsy at some point in their care [1, 2]. Depending on the characteristics of the lesion, biopsy techniques may vary in the type (ie, fine-needle aspiration [FNA], core needle [CNB], vacuum-assisted [VAB]) and in the modality used for imaging guidance (ultrasound [US], mammography, magnetic resonance imaging [MRI]). As with any invasive procedure, it is important to try to minimize the patient’s overall discomfort and pain perception, and recognize what factors may contribute to this, especially as pain and discomfort may affect future adherence to screening [3]. Although a commonly performed procedure, previously published literature regarding the impact of …