作者
Srinivas Nagaraj, Je-In Youn, Hannah Weber, Cristina Iclozan, Lily Lu, Matthew J Cotter, Colin Meyer, Carlos R Becerra, Mayer Fishman, Scott Antonia, Michael B Sporn, Karen T Liby, Bhupendra Rawal, Ji-Hyun Lee, Dmitry I Gabrilovich
发表日期
2010/3/15
期刊
Clinical cancer research
卷号
16
期号
6
页码范围
1812-1823
出版商
American Association for Cancer Research
简介
Purpose: Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means to modulate these cells.
Experimental Design: We evaluated the effect of the synthetic triterpenoid C-28 methyl ester of 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid (CDDO-Me; bardoxolone methyl) in MC38 colon carcinoma, Lewis lung carcinoma, and EL-4 thymoma mouse tumor models, as well as blood samples from patients with renal cell cancer and soft tissue sarcoma. Samples were also analyzed from patients with pancreatic cancer treated with CDDO-Me in combination with gemcitabine.
Results: CDDO-Me at concentrations of 25 to 100 nmol/L completely abrogated immune suppressive activity of MDSC in vitro. CDDO-Me reduced reactive oxygen species in MDSCs but did …
引用总数
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S Nagaraj, JI Youn, H Weber, C Iclozan, L Lu… - Clinical cancer research, 2010