作者
Michele E Villalobos, Akiko Mizuno, Branelle C Dahl, Nobuko Kemmotsu, Ralph-Axel Müller
发表日期
2005/4/15
期刊
Neuroimage
卷号
25
期号
3
页码范围
916-925
出版商
Academic Press
简介
Some recent evidence has suggested abnormalities of the dorsal stream and possibly the mirror neuron system in autism, which may be responsible for impairments of joint attention, imitation, and secondarily for language delays. The current study investigates functional connectivity along the dorsal stream in autism, examining interregional blood oxygenation level dependent (BOLD) signal cross-correlation during visuomotor coordination. Eight high-functioning autistic men and eight handedness and age-matched controls were included. Visually prompted button presses were performed with the preferred hand. For each subject, functional connectivity was computed in terms of BOLD signal correlation with the mean time series in bilateral visual area 17. Our hypothesis of reduced dorsal stream connectivity in autism was only in part confirmed. Functional connectivity with superior parietal areas was not …
引用总数
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