作者
Tsung-Ta Chiang, Ming-Hsien Chiang, Hung-Jen Tang, Zhi-Yuan Shi, Mao-Wang Ho, Chia-Hui Chou, Shang-Yi Lin, Po-Liang Lu, Ting-Shu Wu, Shian-Sen Shie, Jien-Wei Liu, Feng-Yee Chang, Yin-Ching Chuang, Fu-Der Wang, Ya-Sung Yang
发表日期
2024/2/28
简介
Background
Infections caused by Klebsiella pneumoniae are common and result in high mortality rates. In vitro studies demonstrated the potency of cefoperazone/sulbactam (CPZ/SUL) against Klebsiella pneumoniae. However, the clinical efficacy of CPZ/SUL for the treatment of K. pneumoniae bacteremia has not been studied.
Objectives
This study aimed to correlate the clinical outcomes of patients with bacteremia with the minimal inhibitory concentrations (MICs) of CPZ/SUL against the causative K. pneumoniae isolates.
Methods
This multicenter, retrospective observational study was conducted in Taiwan between July 2017 and April 2021. Patients with K. pneumoniae bacteremia treated with CPZ/SUL were enrolled in this study. CPZ/SUL MICs were determined using the agar dilution method. Data on the patients’ clinical outcomes and characteristics were collected and analyzed.
Results
In total, 201 patients were …
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