作者
E Vianello, E Dozio, F Arnaboldi, MG Marazzi, C Martinelli, J Lamont, L Tacchini, A Sigrüner, G Schmitz, MM Corsi Romanelli
发表日期
2016/3/1
期刊
Nutrition, Metabolism and Cardiovascular Diseases
卷号
26
期号
3
页码范围
246-253
出版商
Elsevier
简介
Background and aims
In coronary artery disease (CAD) epicardial adipose tissue (EAT) shows an elevated inflammatory infiltrate. Toll-like receptors (TLRs) are important mediators of adipose tissue inflammation and they are able to recognize endogenous products released by damaged cells. Because adipocyte death may be driven by hypertrophy, our aim was to investigate in CAD and non-CAD patients the association between EAT adipocyte size, macrophage infiltration/polarization and TLR-2 and TLR-4 expression.
Methods and results
EAT biopsies were collected from CAD and non-CAD patients. The adipocyte size was determined by morphometric analysis. Microarray technology was used for gene expression analysis; macrophage phenotype and TLRs expression were analyzed by immunofluorescence and immunohistochemical techniques. Inflammatory mediator levels were determined by …
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E Vianello, E Dozio, F Arnaboldi, MG Marazzi… - Nutrition, Metabolism and Cardiovascular Diseases, 2016