作者
Jorrit S Lemkes, Gladys N Janssens, Nina W van der Hoeven, Lucia SD Jewbali, Eric A Dubois, Martijn Meuwissen, Tom A Rijpstra, Hans A Bosker, Michiel J Blans, Gabe B Bleeker, Rémon Baak, Georgios J Vlachojannis, Bob JW Eikemans, Pim van der Harst, Iwan CC van der Horst, Michiel Voskuil, Joris J van der Heijden, Albertus Beishuizen, Martin Stoel, Cyril Camaro, Hans van der Hoeven, José P Henriques, Alexander PJ Vlaar, Maarten A Vink, Bas van den Bogaard, Ton ACM Heestermans, Wouter de Ruijter, Thijs SR Delnoij, Harry JGM Crijns, Gillian AJ Jessurun, Pranobe V Oemrawsingh, Marcel TM Gosselink, Koos Plomp, Michael Magro, Paul WG Elbers, Peter M van de Ven, Heleen M Oudemans-van Straaten, Niels van Royen
发表日期
2019/4/11
期刊
New England Journal of Medicine
卷号
380
期号
15
页码范围
1397-1407
出版商
Massachusetts Medical Society
简介
Background
Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role of immediate coronary angiography and percutaneous coronary intervention (PCI) in the treatment of patients who have been successfully resuscitated after cardiac arrest in the absence of ST-segment elevation myocardial infarction (STEMI) remains uncertain.
Methods
In this multicenter trial, we randomly assigned 552 patients who had cardiac arrest without signs of STEMI to undergo immediate coronary angiography or coronary angiography that was delayed until after neurologic recovery. All patients underwent PCI if indicated. The primary end point was survival at 90 days. Secondary end points included survival at 90 days with good cerebral performance or mild or moderate disability, myocardial injury, duration of catecholamine support, markers of shock, recurrence of ventricular tachycardia, duration of …
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JS Lemkes, GN Janssens, NW van der Hoeven… - New England Journal of Medicine, 2019