作者
Pieter J Vlaar, Tone Svilaas, Iwan C van der Horst, Gilles FH Diercks, Marieke L Fokkema, Bart JGL de Smet, Ad FM van den Heuvel, Rutger L Anthonio, Gillian A Jessurun, Eng-Shiong Tan, Albert JH Suurmeijer, Felix Zijlstra
发表日期
2008/6/7
期刊
The Lancet
卷号
371
期号
9628
页码范围
1915-1920
出版商
Elsevier
简介
Background
Percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction can be complicated by spontaneous or angioplasty-induced embolisation of atherothrombotic material. Distal blockage induces microvascular obstruction and can result in less than optimum reperfusion of viable myocardium. The Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS) found that thrombus aspiration resulted in improved myocardial reperfusion compared with conventional PCI, but whether this benefit improves clinical outcome is unknown. We aimed to investigate whether the early efficacy of thrombus aspiration seen in TAPAS translated into clinical benefit after 1 year.
Methods
Patients with ST-elevation myocardial infarction enrolled at the University Medical Centre Groningen were randomly assigned in a 1:1 ratio to either thrombus aspiration or …
引用总数
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PJ Vlaar, T Svilaas, IC van der Horst, GFH Diercks… - The Lancet, 2008