作者
Mariska Bot, Yuri Milaneschi, Tahani Al-Shehri, Najaf Amin, Sanzhima Garmaeva, Gerrit LJ Onderwater, Rene Pool, Carisha S Thesing, Lisanne S Vijfhuizen, Nicole Vogelzangs, Ilja CW Arts, Ayse Demirkan, Cornelia van Duijn, Marleen van Greevenbroek, Carla JH van der Kallen, Sebastian Köhler, Lannie Ligthart, Arn MJM van den Maagdenberg, Dennis O Mook-Kanamori, Renée de Mutsert, Henning Tiemeier, Miranda T Schram, Coen DA Stehouwer, Gisela M Terwindt, Ko Willems van Dijk, Jingyuan Fu, Alexandra Zhernakova, Marian Beekman, P Eline Slagboom, Dorret I Boomsma, Brenda WJH Penninx, M Beekman, HED Suchiman, J Deelen, N Amin, JW Beulens, JA van der Bom, N Bomer, A Demirkan, JA van Hilten, JMTA Meessen, R Pool, MH Moed, J Fu, GLJ Onderwater, F Rutters, C So-Osman, WM van der Flier, AAWA van der Heijden, A van der Spek, FW Asselbergs, E Boersma, PM Elders, JM Geleijnse, MA Ikram, M Kloppenburg, I Meulenbelt, SP Mooijaart, RGHH Nelissen, MG Netea, BWJH Penninx, CDA Stehouwer, CE Teunissen, GM Terwindt, AMJM van den Maagdenberg, P van der Harst, ICC van der Horst, CJH van der Kallen, MMJ van Greevenbroek, WE van Spil, C Wijmenga, AH Zwinderman, A Zhernikova, JW Jukema, N Sattar
发表日期
2020/3/1
期刊
Biological psychiatry
卷号
87
期号
5
页码范围
409-418
出版商
Elsevier
简介
Background
Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic markers, predominantly lipids, was compared between depressed and nondepressed persons.
Methods
Nine Dutch cohorts were included, comprising 10,145 control subjects and 5283 persons with depression, established with diagnostic interviews or questionnaires. A proton nuclear magnetic resonance metabolomics platform provided 230 metabolite measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition and particle concentration measures of lipoprotein subclasses; and 81 lipid and fatty acids ratios. For each metabolite measure, logistic regression analyses adjusted for gender, age, smoking, fasting status, and lipid-modifying medication were performed within cohort, followed by random-effects meta-analyses …
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M Bot, Y Milaneschi, T Al-Shehri, N Amin, S Garmaeva… - Biological psychiatry, 2020