作者
Surya P Bhatt, Xavier Soler, Xin Wang, Susan Murray, Antonio R Anzueto, Terri H Beaty, Aladin M Boriek, Richard Casaburi, Gerard J Criner, Alejandro A Diaz, Mark T Dransfield, Douglas Curran-Everett, Craig J Galbán, Eric A Hoffman, James C Hogg, Ella A Kazerooni, Victor Kim, Gregory L Kinney, Amir Lagstein, David A Lynch, Barry J Make, Fernando J Martinez, Joe W Ramsdell, Rishindra Reddy, Brian D Ross, Harry B Rossiter, Robert M Steiner, Matthew J Strand, Edwin JR Van Beek, Emily S Wan, George R Washko, J Michael Wells, Chris H Wendt, Robert A Wise, Edwin K Silverman, James D Crapo, Russell P Bowler, MeiLan K Han
发表日期
2016/7/15
期刊
American journal of respiratory and critical care medicine
卷号
194
期号
2
页码范围
178-184
出版商
American Thoracic Society
简介
Rationale: The small conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary disease and may precede emphysema development.
Objectives: We hypothesized a novel computed tomography (CT) biomarker of small airway disease predicts FEV1 decline.
Methods: We analyzed 1,508 current and former smokers from COPDGene with linear regression to assess predictors of change in FEV1 (ml/yr) over 5 years. Separate models for subjects without and with airflow obstruction were generated using baseline clinical and physiologic predictors in addition to two novel CT metrics created by parametric response mapping (PRM), a technique pairing inspiratory and expiratory CT images to define emphysema (PRMemph) and functional small airways disease (PRMfSAD), a measure of nonemphysematous air trapping.
Measurements and Main Results: Mean (SD) rate of FEV1 decline in …
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SP Bhatt, X Soler, X Wang, S Murray, AR Anzueto… - American journal of respiratory and critical care …, 2016