作者
Rachel K Putman, Hiroto Hatabu, Tetsuro Araki, Gunnar Gudmundsson, Wei Gao, Mizuki Nishino, Yuka Okajima, Josée Dupuis, Jeanne C Latourelle, Michael H Cho, Souheil El-Chemaly, Harvey O Coxson, Bartolome R Celli, Isis E Fernandez, Oscar E Zazueta, James C Ross, Rola Harmouche, Raúl San José Estépar, Alejandro A Diaz, Sigurdur Sigurdsson, Elías F Gudmundsson, Gudny Eiríksdottír, Thor Aspelund, Matthew J Budoff, Gregory L Kinney, John E Hokanson, Michelle C Williams, John T Murchison, William MacNee, Udo Hoffmann, Christopher J O’Donnell, Lenore J Launer, Tamara B Harrris, Vilmundur Gudnason, Edwin K Silverman, George T O’Connor, George R Washko, Ivan O Rosas, Gary M Hunninghake
发表日期
2016/2/16
期刊
Jama
卷号
315
期号
7
页码范围
672-681
出版商
American Medical Association
简介
Importance
Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our knowledge, an association with mortality has not been previously investigated.
Objective
To investigate whether interstitial lung abnormalities are associated with increased mortality.
Design, Setting, and Population
Prospective cohort studies of 2633 participants from the FHS (Framingham Heart Study; computed tomographic [CT] scans obtained September 2008-March 2011), 5320 from the AGES-Reykjavik Study (Age Gene/Environment Susceptibility; recruited January 2002-February 2006), 2068 from the COPDGene Study (Chronic Obstructive Pulmonary Disease; recruited November 2007-April 2010), and 1670 from ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints; between December 2005 …
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RK Putman, H Hatabu, T Araki, G Gudmundsson… - Jama, 2016