作者
Allison A Lambert, Nirupama Putcha, M Bradley Drummond, Aladin M Boriek, Nicola A Hanania, Victor Kim, Gregory L Kinney, Merry-Lynn N McDonald, Emily P Brigham, Robert A Wise, Meredith C McCormack, Nadia N Hansel, COPDGene Investigators
发表日期
2017/1/1
期刊
Chest
卷号
151
期号
1
页码范围
68-77
出版商
Elsevier
简介
Background
Obesity is prevalent in the United States; however, the impact of obesity on COPD morbidity is unclear. We hypothesized that obesity is associated with worse outcomes in COPD.
Methods
We examined 3,631 participants from the multicenter prospective cohort study Genetic Epidemiology of COPD (COPDGene) who had spirometry-confirmed COPD, a postbronchodilator FEV1 < 80% predicted, and a BMI ≥ 18.5 kg/m2. We conducted logistic and linear regression analyses to determine the association between COPD outcomes and obesity class, adjusting for relevant confounders. The referent for obesity classes included normal/overweight individuals (BMI range, 18.5-29.9 kg/m2).
Results
Overall, 35% of participants were obese, with 21% class I (BMI range, 30-34.9 kg/m2), 9% class II (BMI range, 35-39.9 kg/m2), and 5% class III (BMI ≥ 40 kg/m2). The number of comorbidities increased with increasing …
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AA Lambert, N Putcha, MB Drummond, AM Boriek… - Chest, 2017