作者
Katherine E Lowe, Elizabeth A Regan, Antonio Anzueto, Erin Austin, John HM Austin, Terri H Beaty, Panayiotis V Benos, Christopher J Benway, Surya P Bhatt, Eugene R Bleecker, Sandeep Bodduluri, Jessica Bon, Aladin M Boriek, Adel RE Boueiz, Russell P Bowler, Matthew Budoff, Richard Casaburi, Peter J Castaldi, Jean-Paul Charbonnier, Michael H Cho, Alejandro Comellas, Douglas Conrad, Corinne Costa Davis, Gerard J Criner, Douglas Curran-Everett, Jeffrey L Curtis, Dawn L DeMeo, Alejandro A Diaz, Mark T Dransfield, Jennifer G Dy, Ashraf Fawzy, Margaret Fleming, Eric L Flenaugh, Marilyn G Foreman, Spyridon Fortis, Hirut Gebrekristos, Sarah Grant, Philippe A Grenier, Tian Gu, Abhya Gupta, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Lystra P Hayden, Craig P Hersh, Brian D Hobbs, Eric A Hoffman, James C Hogg, John E Hokanson, Karin F Hoth, Albert Hsiao, Stephen Humphries, Kathleen Jacobs, Francine L Jacobson, Ella A Kazerooni, Victor Kim, Woo Jin Kim, Gregory L Kinney, Harald Koegler, Sharon M Lutz, David A Lynch, Neil R MacIntye Jr, Barry J Make, Nathaniel Marchetti, Fernando J Martinez, Diego J Maselli, Anne M Mathews, Meredith C McCormack, Merry-Lynn N McDonald, Charlene E McEvoy, Matthew Moll, Sarah S Molye, Susan Murray, Hrudaya Nath, John D Newell Jr, Mariaelena Occhipinti, Matteo Paoletti, Trisha Parekh, Massimo Pistolesi, Katherine A Pratte, Nirupama Putcha, Margaret Ragland, Joseph M Reinhardt, Stephen I Rennard, Richard A Rosiello, James C Ross, Harry B Rossiter, Ingo Ruczinski, Raul San Jose Estepar, Frank C Sciurba, Jessica C Sieren, Harjinder Singh, Xavier Soler, Robert M Steiner, Matthew J Strand, William W Stringer, Ruth Tal-Singer, Byron Thomashow, Gonzalo Vegas Sánchez-Ferrero, John W Walsh, Emily S Wan, George R Washko, J Michael Wells, Chris H Wendt, Gloria Westney, Ava Wilson, Robert A Wise, Andrew Yen, Kendra Young, Jeong Yun, Edwin K Silverman, James D Crapo
发表日期
2019
期刊
Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
卷号
6
期号
5
页码范围
384
出版商
COPD Foundation
简介
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of individuals without spirometric evidence of COPD who suffer from respiratory symptoms and/or increased morbidity and mortality. There is a clear need for an expanded definition of COPD that is linked to physiologic, structural (computed tomography [CT]) and clinical evidence of disease. Using data from the COPD Genetic Epidemiology study (COPDGene®), we hypothesized that an integrated approach that includes environmental exposure, clinical symptoms, chest CT imaging and spirometry better defines disease and captures the likelihood of progression of respiratory obstruction and mortality.
Methods: Four key disease characteristics–environmental exposure …
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KE Lowe, EA Regan, A Anzueto, E Austin, JHM Austin… - Chronic Obstructive Pulmonary Diseases: Journal of …, 2019