作者
Raúl San José Estépar, Gregory L Kinney, Jennifer L Black-Shinn, Russell P Bowler, Gordon L Kindlmann, James C Ross, Ron Kikinis, MeiLan K Han, Carolyn E Come, Alejandro A Diaz, Michael H Cho, Craig P Hersh, Joyce D Schroeder, John J Reilly, David A Lynch, James D Crapo, J Michael Wells, Mark T Dransfield, John E Hokanson, George R Washko, COPDGene Study
发表日期
2013/7/15
期刊
American journal of respiratory and critical care medicine
卷号
188
期号
2
页码范围
231-239
出版商
American Thoracic Society
简介
Rationale: Angiographic investigation suggests that pulmonary vascular remodeling in smokers is characterized by distal pruning of the blood vessels.
Objectives: Using volumetric computed tomography scans of the chest we sought to quantitatively evaluate this process and assess its clinical associations.
Methods: Pulmonary vessels were automatically identified, segmented, and measured. Total blood vessel volume (TBV) and the aggregate vessel volume for vessels less than 5 mm2 (BV5) were calculated for all lobes. The lobe-specific BV5 measures were normalized to the TBV of that lobe and the nonvascular tissue volume (BV5/TissueV) to calculate lobe-specific BV5/TBV and BV5/TissueV ratios. Densitometric measures of emphysema were obtained using a Hounsfield unit threshold of −950 (%LAA-950). Measures of chronic obstructive pulmonary disease severity included single breath measures of …
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RSJ Estépar, GL Kinney, JL Black-Shinn, RP Bowler… - American journal of respiratory and critical care …, 2013