作者
Michèle Hubli, John LK Kramer, Catherine R Jutzeler, Jan Rosner, Julio C Furlan, Keith E Tansey, Martin Schubert
发表日期
2019/11
来源
Spinal Cord
卷号
57
期号
11
页码范围
909-923
出版商
Nature Publishing Group UK
简介
Study design
Narrative review.
Objectives
To discuss how electrophysiology may contribute to future clinical trials in spinal cord injury (SCI) in terms of: (1) improvement of SCI diagnosis, patient stratification and determination of exclusion criteria; (2) the assessment of adverse events; and (3) detection of therapeutic effects following an intervention.
Methods
An international expert panel for electrophysiological measures in SCI searched and discussed the literature focused on the topic.
Results
Electrophysiology represents a valid method to detect, track, and quantify readouts of nerve functions including signal conduction, e.g., evoked potentials testing long spinal tracts, and neural processing, e.g., reflex testing. Furthermore, electrophysiological measures can predict functional outcomes and thereby guide rehabilitation programs and therapeutic interventions for clinical studies.
Conclusion
Objective and quantitative …
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M Hubli, JLK Kramer, CR Jutzeler, J Rosner, JC Furlan… - Spinal Cord, 2019