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Research has demonstrated the importance of job characteristics to explain work-to-family enrichment (WFE) and the value of this enrichment to explain employees’ wellbeing. However, there is no comprehensive framework to explain the relationship between these variables. This study uses the Job Demands-Control-Support model as a guiding framework, and examines the relationship between these job characteristics and WFE and, more interestingly, the WFE as a mechanism for explaining the relationship between job characteristics and employees’ well-being. Furthermore, we analyzed the relationship of employees’ perceptions of High Performance Work System (HPWS) with job characteristics. With a sample of 1,390 employees from a Portuguese bank, job demands were found to be negatively related to WFE while autonomy and supervisor support displayed a positive relation. We also observed …