作者
Sandra V Pirela, Isabelle R Miousse, Xiaoyan Lu, Vincent Castranova, Treye Thomas, Yong Qian, Dhimiter Bello, Lester Kobzik, Igor Koturbash, Philip Demokritou
发表日期
2016/2
期刊
Environmental health perspectives
卷号
124
期号
2
页码范围
210-219
出版商
National Institute of Environmental Health Sciences
简介
Background
Engineered nanomaterials (ENMs) incorporated into toner formulations of printing equipment become airborne during consumer use. Although information on the complex physicochemical and toxicological properties of both toner powders and printer-emitted particles (PEPs) continues to grow, most toxicological studies have not used the actual PEPs but rather have primarily used raw toner powders, which are not representative of current exposures experienced at the consumer level during printing.
Objectives
We assessed the biological responses of a panel of human cell lines to PEPs.
Methods
Three physiologically relevant cell lines—small airway epithelial cells (SAECs), macrophages (THP-1 cells), and lymphoblasts (TK6 cells)—were exposed to PEPs at a wide range of doses (0.5–100 μg/mL) corresponding to human inhalation exposure durations at the consumer level of 8 hr or more. Following …
学术搜索中的文章
SV Pirela, IR Miousse, X Lu, V Castranova, T Thomas… - Environmental health perspectives, 2016