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Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 (PIN1), which regulates the conformation of Pro-directed phosphorylation sites, has been identified as a critical catalyst involved in multiple oncogenic signaling pathways. Recently, it has been demonstrated that several putative functional polymorphisms of PIN1 gene were associated with cancer risk. This study examined whether genetic polymorphisms in promoter of PIN1 are associated with esophageal carcinoma susceptibility. Two common polymorphisms in PIN1, rs2233678 (−842G>C) and rs2233679 (−667C>T) were genotyped in this hospital-based case–control study of 699 esophageal carcinoma patients and 729 healthy controls. The results revealed that compared with the most common −842GG genotype carriers, the carriers of −842C variant genotypes (GC+CC) had significantly decreased risk of esophageal carcinoma [odds ratio (OR …