作者
Lucas Sedeno, Olivier Piguet, Sofia Abrevaya, Horacio Desmaras, Indira García‐Cordero, Sandra Baez, Laura Alethia de la Fuente, Pablo Reyes, Sicong Tu, Sebastian Moguilner, Nicolas Lori, Ramon Landin‐Romero, Diana Matallana, Andrea Slachevsky, Teresa Torralva, Dante Chialvo, Fiona Kumfor, Adolfo M García, Facundo Manes, John R Hodges, Agustin Ibanez
发表日期
2017/8
期刊
Human brain mapping
卷号
38
期号
8
页码范围
3804-3822
简介
Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease‐modifying agents, fostering timely therapeutic interventions, and alleviating associated financial costs. Functional connectivity (FC) analysis represents a promising approach to identify early biomarkers in specific diseases. Yet, virtually no study has tested whether potential FC biomarkers prove to be reliable and reproducible across different centers. As such, their implementation remains uncertain due to multiple sources of variability across studies: the numerous international centers capable conducting FC research vary in their scanning equipment and their samples’ socio‐cultural background, and, more troublingly still, no gold‐standard method exists to analyze FC. In this unprecedented study, we aim to address both issues by performing the first multicenter FC research in the …
引用总数
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