作者
Hannah H Chen, Norman Händel, Joanne Ngeow, James Muller, Michael Hühn, Huei-Ting Yang, Mario Heindl, Roos-Marijn Berbers, Ahmed N Hegazy, Janina Kionke, Lamis Yehia, Ulrich Sack, Frank Bläser, Anne Rensing-Ehl, Julia Reifenberger, Julia Keith, Simon Travis, Andreas Merkenschlager, Wieland Kiess, Christian Wittekind, Lisa Walker, Stephan Ehl, Stefan Aretz, Michael L Dustin, Charis Eng, Fiona Powrie, Holm H Uhlig
发表日期
2017/2/1
期刊
Journal of Allergy and Clinical Immunology
卷号
139
期号
2
页码范围
607-620. e15
出版商
Mosby
简介
Background
Patients with heterozygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experience autoimmunity and lymphoid hyperplasia.
Objectives
Because regulation of the phosphoinositide 3-kinase (PI3K) pathway is critical for maintaining regulatory T (Treg) cell functions, we investigate Treg cells in patients with heterozygous germline PTEN mutations (PTEN hamartoma tumor syndrome [PHTS]).
Methods
Patients with PHTS were assessed for immunologic conditions, lymphocyte subsets, forkhead box P3 (FOXP3)+ Treg cell levels, and phenotype. To determine the functional importance of phosphatases that control the PI3K pathway, we assessed Treg cell induction in vitro, mitochondrial depolarization, and recruitment of PTEN to the immunologic synapse.
Results
Autoimmunity and peripheral lymphoid hyperplasia were found in 43% of 79 patients with PHTS …
学术搜索中的文章
HH Chen, N Händel, J Ngeow, J Muller, M Hühn… - Journal of Allergy and Clinical Immunology, 2017