作者
Guoying Wang, Sara Divall, Sally Radovick, David Paige, Yi Ning, Zhu Chen, Yuelong Ji, Xiumei Hong, Sheila O Walker, Deanna Caruso, Colleen Pearson, Mei-Cheng Wang, Barry Zuckerman, Tina L Cheng, Xiaobin Wang
发表日期
2014/2/12
期刊
Jama
卷号
311
期号
6
页码范围
587-596
出版商
American Medical Association
简介
Importance
Although previous reports have linked preterm birth with insulin resistance in children and adults, it is not known whether altered insulin homeostasis is detectable at birth and tracks from birth through childhood.
Objective
To investigate whether preterm birth is associated with elevated plasma insulin levels at birth and whether this association persists into early childhood.
Design, Setting, and Participants
A prospective birth cohort of 1358 children recruited at birth from 1998 to 2010 and followed-up with prospectively from 2005 to 2012 at the Boston Medical Center in Massachusetts.
Main Outcomes and Measures
Random plasma insulin levels were measured at 2 time points: at birth (cord blood) and in early childhood (venous blood). The median age was 1.4 years (interquartile range [IQR], 0.8-3.3) among 4 gestational age groups: full term (≥39 wk), early term (37-38 wk), late preterm (34-36 wk), and …
学术搜索中的文章
G Wang, S Divall, S Radovick, D Paige, Y Ning, Z Chen… - Jama, 2014