作者
Linda A Merlino, Jeffrey Curtis, Ted R Mikuls, James R Cerhan, Lindsey A Criswell, Kenneth G Saag
发表日期
2004/1
期刊
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
卷号
50
期号
1
页码范围
72-77
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Vitamin D is a potent regulator of calcium homeostasis and may have immunomodulatory effects. The influence of vitamin D on human autoimmune disease has not been well defined. The purpose of this study was to evaluate the association of dietary and supplemental vitamin D intake with rheumatoid arthritis (RA) incidence.
Methods
We analyzed data from a prospective cohort study of 29,368 women of ages 55–69 years without a history of RA at study baseline in 1986. Diet was ascertained using a self‐administered, 127‐item validated food frequency questionnaire that included supplemental vitamin D use. Risk ratios (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards regression, adjusting for potential confounders.
Results
Through 11 years of followup, 152 cases of RA were validated against medical records. Greater intake (highest versus lowest …
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