作者
Jeremy Sokolove, Dannette S Johnson, Lauren J Lahey, Catriona A Wagner, Danye Cheng, Geoffrey M Thiele, Kaleb Michaud, Harlan Sayles, Andreas M Reimold, Liron Caplan, Grant W Cannon, Gail Kerr, Ted R Mikuls, William H Robinson
发表日期
2014/4
期刊
Arthritis & rheumatology
卷号
66
期号
4
页码范围
813-821
简介
Objective
The co‐occurrence of rheumatoid factor (RF) and anti–citrullinated protein antibody (ACPA) positivity in rheumatoid arthritis (RA) is well described. However, the mechanisms underlying the potential interaction between these 2 distinct autoantibodies have not been well defined. The aim of this study was to evaluate the epidemiologic and molecular interaction of ACPAs and RF and its association with both disease activity and measures of RA‐associated inflammation.
Methods
In a cohort of 1,488 US veterans with RA, measures of disease activity and serum levels of cytokines and multiplex ACPAs were compared between the following groups of patients: double‐negative (anti–cyclic citrullinated peptide [anti‐CCP]−/RF−), anti‐CCP+/RF−, anti‐CCP−/RF+, or double‐positive (anti‐CCP+/RF+). Additional studies were performed using an in vitro immune complex (IC) stimulation assay in which …
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J Sokolove, DS Johnson, LJ Lahey, CA Wagner… - Arthritis & rheumatology, 2014