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Introduction: Traumatic Brain Injuries (TBI) pose a high risk of developing pituitary insufficiency in patients. We have previously reported alterations in miR-126-3p levels in sera from patients with TBI-induced pituitary deficiency. Methods: To investigate why TBI-induced pituitary deficiency develops only in some patients and to reveal the relationship between miR-126-3p with hormone axes, we used mice epigenetically modified with miR-126-3p at the embryonic stage. These modified mice were subjected to mild-TBI (mTBI) according to the Marmarou-weight-drop model at 2-months of age. Levels of miR-126-3p were assessed one and thirty days in serum after mTBI. Changes in miR-126-3p levels after mTBI of wild-type and miR-126-3p* modified mouse lines validated our human results. Additionally, hypothalamus, pituitary, and adrenal tissues were analyzed for transcripts and associated serum hormone levels …