作者
Jorge Amich, Elaine Bignell
发表日期
2016/8/1
来源
Current opinion in microbiology
卷号
32
页码范围
151-158
出版商
Elsevier Current Trends
简介
Highlights
- Many fungal amino acid biosynthetic pathways are conserved in microbes but absent from humans.
- Several of the involved enzymes have now been found to be essential for fungal viability.
- Therapeutic targets must always be tested in systemic disease, currently not commonplace.
- Much more work required in amino acid biosynthesis in particular in the dimorphic species.
Amongst 1.5 million fatal mycoses of humans occurring annually [1], the vast majority involve the human lung as the primary site of pathogenesis, and are derived from organisms which occupy environmental niches. On entry into the respiratory system pathogenic fungi must draw upon metabolic versatility for survival and proliferation as the mammalian lung is a nutritionally limiting environment. The nutritional stresses encountered have exposed vulnerabilities which have long been viewed as potential antifungal targets, since humans …
学术搜索中的文章
J Amich, E Bignell - Current opinion in microbiology, 2016