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Proper assessment of patients’ needs might enhance patients’ outcomes, ability to cope with new challenges, identify required resources, prioritize service needs, determine patients with higher need levels, and improve patients’ quality of life. A cross-sectional descriptive design was used. Total of 113 patients from different settings completed the study surveys including demographic sheet, Short-form cancer needs questionnaire (CNQ-SF), Functional Assessment of Cancer Therapy-General (FACT-G), and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-INFO 25). Regression analysis indicated that care needs and information needs were predictors of QOL (R² = 0.688, adjusted R² = 0.61, F (1.17, p < 0.001)). A significant correlation exists between QOL, care needs and information needs. Daily nursing practices should include assessing patients; care …