作者
Edmond Atallah, Jane I Grove, Colin Crooks, Esther Burden-Teh, Abhishek Abhishek, Sulleman Moreea, Kelsey M Jordan, Aftab Ala, David Hutchinson, Richard J Aspinall, Ruth Murphy, Guruprasad P Aithal
发表日期
2023/5/1
期刊
Journal of Hepatology
卷号
78
期号
5
页码范围
989-997
出版商
Elsevier
简介
Background & Aims
The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-reported risk factors for liver disease. We evaluated the risk of long-term MTX therapy on liver fibrosis in a longitudinal cohort study using two non-invasive markers.
Method
Between 2014-2021, adult patients diagnosed with rheumatoid arthritis (RA) or psoriasis for ≥2 years were recruited prospectively from six UK sites. The MTX group included patients who received MTX for ≥6 months, whereas the unexposed group included those who never received MTX. All patients underwent full liver profiling, with transient elastography (TE) and enhanced liver fibrosis (ELF) marker measurements.
Results
A total of 999 patients (mean age 60.8 ± 12 years, 62.3% females) were …
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E Atallah, JI Grove, C Crooks, E Burden-Teh… - Journal of Hepatology, 2023