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Many factors and aspects of the construction and operation of buildings depend on climatic parameters and climatic zones, so these will be fundamental for adapting and mitigating the effects of climate change. For this reason, the number of climate-oriented publications in building is increasing. This research presents an analysis on the most-cited climate-oriented studies in building in the period 1979–2019. The main themes, the typologies of these investigations and the principal types of climatic zoning used in these studies were analysed through bibliographic and manual analysis. A broad spectrum of themes directly and indirectly related to climate and climatic zones and buildings was demonstrated. It was found that 88% of all climate-oriented investigations, to one degree or another, are within the scope of the general topic of energy conservation. A thorough understanding of all climate-dependent aspects will help in designing dwellings appropriately in different climate zones. In addition, a methodology that facilitates the establishment of a typology of climate-oriented research is presented. This typology can be used in future research in different scientific areas. It was also revealed that the climate zones of the National Building Codes of China, the USA and Turkey prevailed in the studies analysed.