作者
C Leland Rogers, Sarah K Lageman, James Fontanesi, George D Wilson, Peter A Boling, Surbhi Bansal, John P Karis, Marwan Sabbagh, Minesh P Mehta, Timothy J Harris
发表日期
2023/9/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
117
期号
1
页码范围
87-95
出版商
Elsevier
简介
Purpose
We report neurocognitive, imaging, ophthalmologic, and safety outcomes following low-dose whole brain radiation therapy (LD-WBRT) for patients with early Alzheimer dementia (eAD) treated in a pilot trial.
Methods and Materials
Trial-enrolled patients were at least 55 years of age, had eAD meeting NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association) Alzheimer's Criteria with confirmatory fluorodeoxyglucose and florbetapir positron emission tomography findings; had the capacity to complete neurocognitive function, psychological function, and quality-of-life assessments; had a Rosen modified Hachinski score ≤4; and had estimated survival >12 months.
Results
Five patients were treated with LD-WBRT (2 Gy × 5 over 1 week; 3 female; mean age, 73.2 years [range, 69-77]). Four of 5 patients had improved …
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CL Rogers, SK Lageman, J Fontanesi, GD Wilson… - International Journal of Radiation Oncology* Biology …, 2023