作者
Trevor W Robbins, M James, AM Owen, Klaus W Lange, AJ Lees, PN Leigh, CD Marsden, NP Quinn, BA Summers
发表日期
1994/1/1
期刊
Journal of Neurology, Neurosurgery & Psychiatry
卷号
57
期号
1
页码范围
79-88
出版商
BMJ Publishing Group Ltd
简介
Groups of patients with idiopathic Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy or Steele-Richardson-Olszewski syndrome, matched for overall clinical disability, were compared using three computerised cognitive tests previously shown to be sensitive to frontal lobe dysfunction. On a test of planning based on the Tower of London task, all three groups were impaired, but in different ways. The groups with palsy and Parkinson's disease were slower in the measure of initial thinking time, whereas the group with multiple system atrophy was only slower in a measure of thinking time subsequent to the first move, resembling patients with frontal lobe damage. On a test of spatial working memory, each group showed deficits relative to their matched control groups, but the three groups differed in their strategy for dealing with this task. On a test of attentional set shifting, each group was …
引用总数
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