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This guidance provides a data-supported approach to the diagnosis, staging, and treatment of patients diagnosed with hepatocellular carcinoma (HCC). A guidance document is different from a guideline. Guidelines are developed by a multidisciplinary panel of experts who rate the quality (level) of the evidence and the strength of each recommendation using the Grading of Recommendations Assessment, Development, and Evaluation system (GRADE). A guidance document is developed by a panel of experts in the topic, and guidance statements, not recommendations, are put forward to help clinicians understand and implement the most recent evidence.

Guidelines for HCC were recently developed according to the GRADE approach. 1 The Guidelines for HCC were developed using clinically relevant questions, which were then answered by systematic reviews of the literature, and followed by data-supported …