作者
Norma Maugeri, Rebecca De Lorenzo, Nicola Clementi, Roberta Antonia Diotti, Elena Criscuolo, Cosmo Godino, Cristina Tresoldi, Chiara Bonini, Massimo Clementi, Nicasio Mancini, Fabio Ciceri, Patrizia Rovere‐Querini, Angelo A Manfredi, Bio Angels for COVID‐BioB Study Group
发表日期
2022/2/1
期刊
Journal of Thrombosis and Haemostasis
卷号
20
期号
2
页码范围
434-448
出版商
Elsevier
简介
Background
Platelet activation and thrombotic events characterizes COVID‐19.
Objectives
To characterize platelet activation and determine if SARS‐CoV‐2 induces platelet activation.
Patients/Methods
We investigated platelet activation in 119 COVID‐19 patients at admission in a university hospital in Milan, Italy, between March 18 and May 5, 2020. Sixty‐nine subjects (36 healthy donors, 26 patients with coronary artery disease, coronary artery disease, and seven patients with sepsis) served as controls.
Results
COVID‐19 patients had activated platelets, as assessed by the expression and distribution of HMGB1 and von Willebrand factor, and by the accumulation of platelet‐derived (plt) extracellular vesicles (EVs) and HMGB1+ plt‐EVs in the plasma. P‐selectin upregulation was not detectable on the platelet surface in a fraction of patients (55%) and the concentration of soluble P‐selectin in the plasma was …
学术搜索中的文章
N Maugeri, R De Lorenzo, N Clementi, RA Diotti… - Journal of Thrombosis and Haemostasis, 2022