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Repeatedly negative prostate biopsies in individuals with elevated prostate specific antigen (PSA) levels can be frustrating for both the patient and the urologist. This study was performed to investigate if magnetic resonance imaging (MRI)-guided transrectal biopsy increases diagnostic performance in individuals with elevated or increasing PSA levels after previous negative conventional transrectal ultrasound (TRUS)-guided biopsies.

27 consecutive men with a PSA >4ng/ml and/or suspicious finding on digital rectal examination, suspicious MRI findings, and at least one prior negative prostate biopsy were included. Median age was 66 years (mean, 64.5±6.8); median PSA was 10.2ng/ml (mean, 11.3±5.5). MRI-guided biopsy was performed with a closed unit at 1.5Tesla, an MRI-compatible biopsy device, a needle guide, and a titanium double-shoot biopsy gun.

Median prostate …