作者
Stella Rosson, Renato De Filippis, Giovanni Croatto, Enrico Collantoni, Simone Pallottino, Daniel Guinart, Andre R Brunoni, Bernardo Dell’Osso, Giorgio Pigato, Joshua Hyde, Valerie Brandt, Samuele Cortese, Jess G Fiedorowicz, Georgios Petrides, Christoph U Correll, Marco Solmi
发表日期
2022/8/1
来源
Neuroscience & Biobehavioral Reviews
卷号
139
页码范围
104743
出版商
Pergamon
简介
Background
The degree of efficacy, safety, quality, and certainty of meta-analytic evidence of biological non-pharmacological treatments in mental disorders is unclear.
Methods
We conducted an umbrella review (PubMed/Cochrane Library/PsycINFO-04-Jul-2021, PROSPERO/CRD42020158827) for meta-analyses of randomized controlled trials (RCTs) on deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electro-convulsive therapy (ECT), and others. Co-primary outcomes were standardized mean differences (SMD) of disease-specific symptoms, and acceptability (for all-cause discontinuation). Evidence was assessed with AMSTAR/AMSTAR-Content/GRADE.
Results
We selected 102 meta-analyses. Effective interventions compared to sham were in depressive disorders: ECT (SMD=0.91/GRADE=moderate), TMS (SMD=0.51/GRADE=moderate …
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