作者
Daniel Guinart, Fuminari Misawa, Jose M Rubio, Justin Pereira, Harshit Sharma, Georgios Schoretsanitis, John M Kane, Christoph U Correll
发表日期
2020/11/24
来源
The Journal of Clinical Psychiatry
卷号
82
期号
1
页码范围
13591
出版商
Physicians Postgraduate Press, Inc.
简介
Objective: This systematic review and pooled, patient-level analysis of neuroleptic malignant syndrome (NMS) case reports and series compared NMS characteristics and outcomes during long-acting injectable antipsychotic (LAI) versus oral antipsychotic (OAP) treatment.
Data Sources: Two authors independently searched MEDLINE, Embase, Cochrane, CINAHL, and PsycINFO databases for articles in English from database inception until October 9, 2018.
Study Selection: Case reports with author-defined NMS during ongoing antipsychotic treatment or within 1 injection interval of LAIs in adults aged 18-65 years.
Data Extraction: Demographic, clinical, treatment and outcome data were independently extracted following PRISMA guidelines. NMS severity was rated using the Francis-Yacoub scale. Characteristics and outcomes of NMS were compared when occurring during LAI versus OAP treatment, adjusting for …
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D Guinart, F Misawa, JM Rubio, J Pereira, H Sharma… - The Journal of Clinical Psychiatry, 2020