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To update our prior meta‐analysis that showed past major depression (MD+) to be unrelated to smoking cessation outcome.

Eligible trials included 14 from our original review and 28 identified through an updated systematic review (2000–2009). We coded for assessment of past MD, exclusion for recent MD episode (MDE; ≤6 months versus no exclusion), duration/modality of cognitive behavioral treatment (CBT; face‐to‐face versus self‐help) and other factors. To minimize influence of experimental treatments that may selectively benefit MD+ smokers we analyzed placebo/lowest intensity control arms only. Study‐specific ORs for the effect of past MD on short‐term (≤3 months) and long‐term (≥6 months) abstinence were estimated and combined using random effects. Two‐way interaction models of past MD with study methodology and treatment factors were used to evaluate hypothesized …