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Gliomas infiltrating the corpus callosum (G-I-CC) may carry significant tumor burden by causing severe neurocognitive and functional impairments. The role of surgical resection has been widely debated over the years, as it has been correlated with significant survival improvement but may also predispose the patient to major post-operative complication risks. The aim of our systematic review was to comprehensively analyze the current literature on G-I-CC, describing clinical presentations, management strategies, outcomes, and prognoses. We found that most G-I-CC are IDH-wildtype grade-4 glioblastomas involving the corpus callosum genu and with bilateral lobe infiltration. In patients with high-grade G-I-CC, surgical resection, especially gross-total, led to significantly longer survival when coupled with post-surgery radiation and temozolomide. Rates of symptom improvement and complications did not significantly differ in preservation versus resection of tumor-infiltrated corpus callosum. Overall, maximally safe resection should be considered in patients with G-I-CC, co-adjuvated with intraoperative neuromonitoring and cortical mapping to further reduce complication risks.

Background: Gliomas infiltrating the corpus callosum (G-I-CC) majorly impact patient quality-of-life, but maximally safe tumor resection is challenging. We systematically reviewed the literature on G-I-CC. Methods: PubMed, EMBASE, Scopus, Web of Science, and Cochrane were searched following the PRISMA guidelines to include studies of patients with G-I-CC. Clinicopathological features, treatments, and …